Curative effects of the ethanolic extract of leaves of Solanum torvum on obese, diabetic -induced albino rats

International Journal of Biotech Trends and Technology (IJBTT)
© 2012 by IJBTT Journal
Volume - 2 Issue - 3                          
Year of Publication : 2012
Authors :Vasuki .R, Rajeswari Hari

Vasuki .R, Rajeswari Hari "Curative effects of the ethanolic extract of leaves of Solanum torvum on obese, diabetic -induced albino rats",International Journal of Biotech Trends and Technology (IJBTT), V2(3):9-15 July - September 2012. Published by Seventh Sense Research Group.


The present study dealt with the investigation of anti-obesity and anti-diabetic effects of ethanolic extract of leaves of Solanum torvum (STE) using obese, diabetic -induced albino rats. The animals received either normal diet, high-fat diet or high-fat diet with additional STEfor 12 weeks. After the end of administration, body weight, plasma glucose, insulin, and liver triglyceride, Cholesterol Content and antioxidant activity were measured. The result revealed that , compared to the high-fat diet group, increases in body weight, plasma glucose and insulin were significantly suppressed for STE groups.STE also proved to possess good antioxidant activity.


1. Henty, EE. Weeds of New Guinea and their control. Department of Forests, Division of Botany. Botany Bulletin 1973; 2: 149-151.
2. Chah, KF, Muko KN, Oboegbulem SI. Antimicrobial activity of methanolic extract of Solanum torvum fruit. Fitoterapia 2000; 71: 187-189.
3. Arthan D, Kittakoop P, Esen A, Svasti J. Furostanol Glycoside 26-O-beta-Glucosidase from the Leaves of Solanum torvum. Phytochem 2006; 67: 27-33.
4.Yuanyuan, L.U., L. Jianguang, H. Xuefeng and K. Lingyi, 2009. Four steroidal glycosides from Solanum torvum and their cytotoxic activities. Steroids, 74: 95–101
5. Ghosh MN. Fundamentals of experimental Pharmacology, Second edition. Calcutta, India: Scientific Book agency .1984: p.154.
6. Reitman, S. and S. Frankel, 1957. A colorimetric method for the determination of serum glutamate oxaloacetate and glutamate pyruvate transaminase. Am. J. Clin. Pathol., 28: 56-56.
7. Kind, P.R. and E.J. King, 1954. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J. Clin. Pathol., 7: 322-326.
8. Rhoads G.G., Gulbrandse C.L., and Kagen A.Serum lipoprotein and coronary artery disease in a population study of Hawaiian Japanese men,N. Eng. J. Med. 1976, 294,293-298.
9. Punitha R., and Manoharan S.,Antihyperglycemic and antilipidperoxidative effects of Pongamia pinnata (Linn.) Pierre flowers in alloxan induced diabetic rats, J.Ethnopharmacol. 2006,105, 39-46.
10. Woodson RF. Statistical methods for the analysis of biomedical data, probability and mathematical statistics Wiley Publication Chichester.1987: 315.
11. L.-K.Han, Y. Kimura, and H. Okuda, “Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet,”International Journal of Obesity, vol. 23, no. 2, pp. 174–179, 1999.
12.S. H. Park, S. K. Ko, and S. H. Chung, “Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice,” Journal of Ethnopharmacology, vol. 102, no. 3, pp. 326–335, 2005.
13 D. R.Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner, “Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, pp. 412–419, 1985.
14Y. Sasaki,W. Suzuki, T. Shimada et al., “Dose dependent development of diabetes mellitus and non-alcoholic steatohepatitis in monosodium glutamate-induced obese mice,” Life Sciences, vol. 85, no. 13-14, pp. 490–498, 2009.
15. Bailey, C.J., 1989. Traditional plant medicines as treatment for diabetes. Diabetes care., 12: 553-64.
16.Complementary medicine is booming world wide, 1996. British medical journal., 313: 131-3.
17. The WHO Expert Committee on Diabetes Mellitus, 1980. Technical Report Series 646, Geneva and World Health Organization.
18. Halberstein, R.A., 2005. Medicinal plants: historical and cross-cultural usage patterns. Ann Epidemiol., 15: 686-99.
19. Mitra, S.K., S. Gopumadhavan, T.S. Muralidhar, S.D. Anturlikar and M.B. Sujatha, 1996. Effect of a herbomineral preparation D-400 in streptozotocin induced diabetic rats. J Ethnopharmacol., 54: 41–46.
20. Sochar, M., N.Z. Baquer and P. Mclean, 1985.Glucose under utilization in diabetes. Comparative studies on the changes in the activities of enzymes of glucose metabolism in rat kidney and liver. Mol Physiol., 7: 51-68.
21. Brunton L.L., Parker K.L., Blumenthal D.K., and Buxton L.O. Insulin, oral hypoglycemic agents and pharmacology of endocrine pancreas, Goodman and Gillman‟s Manual of Pharmacology and therapeutics, The McGraw-Hill Companies, USA, 2008,1048-1068.
22. Katzung B.G., Pancreatic hormone and antidiabetic drugs. Basic & Clinical Pharmacology, edited by Bertram G. Katzung,10th Edition, McGraw Hill,USA,2007, 683-705.

These results suggest that STE is expected to be an useful plant extract for alleviating the adversse effect of obesity associated with diabetes mellitus.