IJBTT

Peganum harmala: a rich source of antimicrobial agents

	International Journal of Biotech Trends and Technology (IJBTT)
	© 2019 by IJBTT Journal
	Volume - 9 Issue - 4
	Year of Publication : 2019
	Authors : Uzma Qaisar
	DOI :  10.14445/22490183/IJBTT-V9I4P602

Citation

MLA Style:Uzma Qaisar "Peganum harmala: a rich source of antimicrobial agents" International Journal of Biotech Trends and Technology 9.4 (2019): 4-7.

APA Style:Uzma Qaisar(2019). Peganum harmala: a rich source of antimicrobial agents. International Journal of Biotech Trends and Technology, 9(4),4-7.

Abstract

Infection causing bacteria are developing resistance against common antibiotics. To treat these antibiotic resistant bacteria, novel effective antimicrobial compounds are synthesized or isolated from various sources. Conventionally, a lot of medicinal plants are used to treat infections caused by pathogens. Peptides isolated from medicinal peptides are gaining a lot of interest owing to their potential to serve as natural antibacterial agents. Peganum harmala is a medicinal plant which contains various natural metabolites, compounds and proteins of pharmaceutical importance. A review of antibacterial agents of P. harmala plants are discussed here.

References

[1] Doughari, J., Antimicrobial activity of Tamarindus indica Linn. Tropical Journal of Pharmaceutical Research, 2006. 5(2): p. 597-603.
[2] Eloff, J., Which extractant should be used for the screening and isolation of antimicrobial components from plants? Journal of ethnopharmacology, 1998. 60(1): p. 1-8.
[3] Holetz, F.B., et al., Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Memórias do Instituto Oswaldo Cruz, 2002. 97(7): p. 1027-1031.
[4] El Astal, Z., A. Ashour, and A. Kerrit, Antimicrobial activity of some medicinal plant extracts in Palestine. Pak. J. Med. Sci, 2005. 21(2): p. 187-193.
[5] Ngunde Ngwendson, J., et al., Constituents of Peucedanum zenkeri seeds and their antimicrobial effects. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2003. 58(8): p. 587-589.
[6] Afzal, M., A. Tayyeb, and U. Qaisar, Commercial Applications of Plant Pigments.
[7] Heinrich, M., et al., Fundamentals of pharmacognosy and phytotheraphy. 2004: Edinburgh, GB: Churchill Livingstone.
[8] Rios, J. and M. Recio, Medicinal plants and antimicrobial activity. Journal of ethnopharmacology, 2005. 100(1-2): p. 80-84.
[9] Mahesh, B. and S. Satish, Antimicrobial activity of some important medicinal plant against plant and human pathogens. World journal of agricultural sciences, 2008. 4(5): p. 839-843.
[10] Arora, D.S. and J. Kaur, Antimicrobial activity of spices. International journal of antimicrobial agents, 1999. 12(3): p. 257-262.
[11] Nostro, A., et al., Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Letters in applied microbiology, 2000. 30(5): p. 379-384.
[12] Fu, Y., et al., Antimicrobial activity of clove and rosemary essential oils alone and in combination. Phytotherapy Research, 2007. 21(10): p. 989-994.
[13] Asgarpanah, J. and F. Ramezanloo, Chemistry, pharmacology and medicinal properties of Peganum harmala L. African Journal of Pharmacy and Pharmacology, 2012. 6(22): p. 1573-1580.
[14] Mirzaie, M., et al., Antileishmanial activity of Peganum harmala extract on the in vitro growth of Leishmania major promastigotes in comparison to a trivalent antimony drug. Veterinarski arhiv, 2007. 77(4): p. 365.
[15] Farzaei, M.H., et al., Parsley: a review of ethnopharmacology, phytochemistry and biological activities. Journal of traditional Chinese medicine, 2013. 33(6): p. 815-826.
[16] Berrougui, H., et al., Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seed`s in isolated rat aorta. Pharmacological research, 2006. 54(2): p. 150-157.
[17] Farouk, L., et al., Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved. Journal of ethnopharmacology, 2008. 115(3): p. 449-454.
[18] Guerbette, F., et al., Lipid-transfer proteins from plants: structure and binding properties. Molecular and cellular biochemistry, 1999. 192(1-2): p. 157-161.
[19] Prashanth, D. and S. John, Antibacterial activity of Peganum harmala. Fitoterapia, 1999. 70(4): p. 438-439.
[20] Darabpour, E., et al., Antibacterial activity of different parts of Peganum harmala L. growing in Iran against multi-drug resistant bacteria. EXCLI journal, 2011. 10: p. 252.
[21] Shahverdi, A.R., et al., Antimicrobial activity and main chemical composition of two smoke condensates from Peganum harmala seeds. Zeitschrift für Naturforschung C, 2005. 60(9-10): p. 707-710.
[22] Moloudizargari, M., et al., Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacognosy reviews, 2013. 7(14): p. 199.
[23] Nenaah, G., Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects. Fitoterapia, 2010. 81(7): p. 779-782.
[24] Duvick, J., et al., Purification and characterization of a novel antimicrobial peptide from maize (Zea mays L.) kernels. Journal of Biological Chemistry, 1992. 267(26): p. 18814-18820.
[25] Luo, J., et al., Study on the antitumor activity of protein extracts of Peganalaum harmala seeds in vitro. Biotechnology, 2010. 20(5): p. 32-34.
[26] Ma, X., et al., Purification and characterization of a novel antifungal protein with antiproliferation and anti-HIV-1 reverse transcriptase activities from Peganum harmala seeds. Acta Biochim Biophys Sin, 2012. 45(2): p. 87-94.
[27] Bauer, R. and L. Dicks, Mode of action of lipid II-targeting lantibiotics. International journal of food microbiology, 2005. 101(2): p. 201-216.
[28] Yang, L., et al., Barrel-stave model or toroidal model? A case study on melittin pores. Biophysical journal, 2001. 81(3): p. 1475-1485.
[29] Jenssen, H., P. Hamill, and R.E. Hancock, Peptide antimicrobial agents. Clinical microbiology reviews, 2006. 19(3): p. 491-511.
[30] Brogden, K.A., Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nature reviews microbiology, 2005. 3(3): p. 238.
[31] Lohner, K. and S. Blondelle, Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibiotics. Combinatorial chemistry & high throughput screening, 2005. 8(3): p. 241-256.

Keywords
antimicrobial peptides, medicinal plants, alkaloids