Occupational Exposure and Its Risks Exposure and Threats

 
 
International Journal of Biotech Trends and Technology (IJBTT)
 
© 2018 by IJBTT Journal
Volume - 8 Issue - 1                          
Year of Publication : 2018
Authors : KarashdeepKaur, RupinderKaur
DOI :  10.14445/22490183/IJBTT-V8I1P605

Citation

KarashdeepKaur, RupinderKaur "Occupational Exposure and Its Risks Exposure and Threats", International Journal of Biotech Trends and Technology (IJBTT), V8(1): 36-42 January - March 2018, Published by Seventh Sense Research Group.

Abstract

Chemicals are widely used in industries. Many chemicals and radiations have bio-importance but the toxic effects of many of them in human biochemistry are of great concern. All these carcinogenic harmful substance pose serious public health issue as they are one of the most widespread environmental and industrial toxins. Hence, there is the need for proper understanding of the conditions, such as the concentrations and states, which make them harmful. It is also important to know their sources, processes, chemical conversions and their modes of deposition to pollute the environment, which essentially supports lives. These are released into the environment by both natural and anthropogenic sources. They percolate into underground waters, moving along water pathways and eventually depositing in the soil. Poisoning and toxicity in animals occur frequently through exchange and co-ordination mechanisms. Exposures to hazardous materials have been associated with a number of serious systemic toxicological effects involving the nervous system, blood-forming organs, reproductive system, lung and kidney. Studies have shown genotoxic effects in workers exposed to toxic chemicals.Occupational exposure assessment is the strategy which helps employers to protect the health of workers who are exposed to chemicals in their workplace. Our study suggest workers comprise the risk group requires adequate safety, precautionary and preventivemeasures could only minimize exposure and the related health hazards.

References

1. L. Zhang, Steinmaus. C, D.A. Eastmond, X.K. Xin, and M.T. Smith, “Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms,” Mutat Res, vol. 681 , pp. 150-168, 2009.
2. W. Nazaroff, B.K. Coleman, H. Destaillats, A.T. Hodgson, D. Liu, M.M. Lunden, B.C. Singer, and C.J. Weschler, “Indoor air chemistry: cleaning agents, ozone and toxic air contaminants Berkeley, CA: Air Resources Board, California Environmental Protection Agency, 2006.
3. T. Kauppinen, J. Toikkanen, D. Pedersen, R. Young, W. Ahrens, P. Boffetta, J. Hansen, H. Kromhout, J. MaquedaBlasco, D. Mirabelli, V. de la Orden-Rivera, B. Pannett, N. Plato, A. Savela, R. Vincent, and M. Kogevinas, “Occupational exposure to carcinogens in the European Union,” Occup Environ Med, vol. 57, pp. 10-8, 2000.
4. IARC, Cadmium. International Agency for Research on Cancer, Lyon, 1993.
5. A. Hildesheim, M. Dosemeci, C.C. Chan, C.J. Chen, Y.J. Cheng, M.M. Hsu, I.H. Chen, B.F. Mittl, B. Sun, P.H. Levine, J.Y. Chen, L.A. Brinton, and C.S. Yang, “Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma,” Cancer Epidemiol Biomarkers Prev, vol. 10, pp. 1145-1153, 2001.
6. R.W. Armstrong, P.B. Imrey, M.S. Lye, M.J. Armstrong, M.C. Yu, and S. Sani, “Nasopharyngeal carcinoma in Malaysian Chinese: occupational exposures to particles, formaldehyde and heat,” Int J Epidemiol, vol. 29, pp. 991-998, 2000.
7. S. Rajendran, “Environment and Health Aspects of Pesticides Use in Indian Agriculture,” Proceeding of ThirdInternational Conference on Environment and health, pp. 353–373, 2003.
8. A.S. Yadav, G. Sehrawat, “Evaluation of Genetic Damage in Farmers Exposed to Pesticide Mixtures,” Int J Hum Genet, vol. 11(2), pp. 105–109, 2011.
9. S.H. Zahm, M.H. Ward, and A. Blair, “Pesticides and cancer,” Occup Med, vol. 12, pp. 269–89, 1997.
10. J.L. Daniels, A.F. Olshan, and D.A. Savitz, “Pesticides and childhood cancers,” Environ Health Perspect, vol. 105, pp. 1068–1077, 1997.
11. W. Zhou, S. Gurubhagavatula, G. Liu, S. Park, D.S. Neuberg, J.C. Wain, T.J. Lynch, L. Su, and D.C. Christiani, “Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy,” Clin Cancer Res, vol.10, pp. 4939-4943, 2004.
12. M. Kogevinas, T. Kauppinen, R. Winkelmann, H. Becher, P.A. Bertazzi, H.B.B.D. Mesquita, D. Coggon, L. Green, E. Johnson, M. Littorin, E. Lynge, D.A. Marlow, J.D. Mathews, M. Neuberger, T. Benn, B. Pennett, N. Pearce, and R. Saracci, “Soft tissue sarcoma and non-Hodgkin`s lymphoma in workers exposed to phenoxy herbicides, chlorophenols, and dioxins, pp. Two nested case-control studies,” Epidemiology, vol. 6(4), pp. 396–402, 1995.
13. I. Baldi, P. Lebailly, B.M. Brahim, L. Letenneur, J.F. Dartigues, and P. Brochard, “Neurodegenerative Diseases and Exposure to Pesticides in the Elderly,” Am J Epidemiol, vol. 157(5), pp. 409–414, 2003.
14. J.F. Viel, B. Challier, A. Pitard, and D. Pobel, “Brain cancer mortality among French farmers: The vineyard pesticide hypothesis,” Arch Environ Health, vol.53, pp 65–70, 1988.
15. C. Bolognesi, “Genotoxicity of pesticides: A review of human biomonitoring studies,” Mutat Res, vol. 543, pp. 251–272, 2003.
16. C. Bolognesi, A. Creus, P.O. Wegman, and R. Marcos, “Micronuclei and pesticide exposure,” Mutagenesis, vol. 26(1), pp. 19–26, 2011.
17. W. Hankeand J. Jurewicz, “The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: an overview of current epidemiological evidence,” Int. J. Occup. Med. Environ. Health, vol. 17, pp. 223–243, 2004.
18. L, Lauria, L. Settimi, A. Spinelli, and F.I.Talamanca, “Exposure to pesticides and time to pregnancy among female greenhouse workers,” Reprod. Toxicol, vol. 22, pp. 425–430, 2006.
19. A. Arruti, I. Fernandez-Olmo, and A. Irabien, “Evaluation of the contribution of local sources to trace metals levels in urban PM2.5 and PM10 in the Cantabria region (Northern Spain),” J Environ Monit, vol. 12, pp. 1451–1458, 2010.
20. G.R. Silva, O.B.M. Alencar, J.S. Teixeira, R. Rodrigues e-Silva, C.J.M. Paz, J. de-Castro-e-Sousa, S.R. de-Aguiar, M.R. de-Carvalho, G.A. Junior, O.F.A. da-Mata, J. de-Oliveira Santos, M. Islam, P.P. Ferreir, de-Carvalho, A. Melo-Cavalcante,and N.J. Picada, “Genotoxicity and DNA Repair Indicative in Blood Cells after Occupational Exposure to Ionizing Radiation,” International Archives Of Medicine, vol. 9, 2016.
21. A. Sahin, A. Tatar, S. Oztas, B. Seven, E. Varoglu, A. Yesilyurt, and A.K. Ayan, “Evaluation of the genotoxic effects of chronic low-dose ionizing radiation exposure on nuclear medicine workers,” Nucl Med Biol, vol. 36(5), pp. 575–578, 2009.
22. J.E. Fergusson, The heavy elements: chemistry, environmental impact and health effects. Pergamon, Oxford, 1990.
24. J.O. Nriagu, “A global assessment of natural sources of atmospheric trace metals,” Nature, vol. 338, pp. 47–49, 1989.
25. H. Bradl, “Heavy metals in the environment: origin, interaction and remediation,” vol 6, Academic, London, 2002.
26. Z.L. He, X.E. Yang, and P.J. Stoffella, “Trace elements in agroecosystems and impacts on the environment,” J Trace Elem Med Biol, vol. 19, pp. 125–140, 2005.
27. S. Shallari, C. Schwartz, A. Hasko, and J.L. Morel, “Heavy metals in soils and plants of serpentine and industrial sites of Albania,” Sci Total Environ, vol. 209, pp. 133–142, 1998.
28. P. Apostoli, P. Kiss, P. Stefano, J.P. Bonde, and M. Vanhoorne, “Male reproduction toxicity of lead in animals and humans,” Occup Environ Med, vol. 55, pp. 364–374, 1998.
29. E. Streater, A. Westbeld, and O. Klemm, “Pollution in coastal fog at Alto Patache, Northern Chile,” Environ SciPollut Res Int, vol. 17, pp. 1563–1573, 2010.
30. J.M. Pacyna, “Monitoring and assessment of metal contaminants in the air,” In: Chang LW, Magos L, Suzuli T, Eds, Toxicology of metals. CRC, Boca Raton, FL, 1996, pp 9–28.
31. B.R. Stern, “Essentiality and toxicity in copper health risk assessment: overview, update and regulatory considerations,” Toxicol Environ Health A, vol. 73, pp. 114–127, 2010.
32. L.J. Harvey, and H.J. McArdle, “Biomarkers of copper status: a brief update,” Br J Nutr, vol. 99, pp. 10–13, 2008.
33. ATSDR, Toxicological profile for copper. Centers for Disease Control, Agency for Toxic Substances and Disease Registry, Atlanta, GA, 2002.
34. P.B. Tchounwou, C. Newsome, J. Williams, and K. Glass, “Copper-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells,” Metal Ions Biol Med, vol. 10, pp. 285–290, 2008
35. ATSDR, Toxicological profile for arsenic TP-92/09. Center for Disease Control, Agency for Toxic Substances and Disease Registry, Atlanta, GA, 2000.
36. P.B. Tchounwou, B. Wilson, and A. Ishaque, “Important considerations in the development of public health advisories for arsenic and arsenic-containing compounds in drinking water,” Rev Environ Health, vol. 14, pp. 211–229, 1999.
37. National Research Council, Arsenic in drinking water. 2001 Update. Online available at http://www.nap.edu/books/0309076293.
38. P.B. Tchounwou, A.K. Patlolla, and J.A. Centeno, “Carcinogenic and systemic health effects associated with arsenic exposure-a critical review,” ToxicolPathol, vol. 31, pp. 575–588, 2003.
39. P.B. Tchounwou, J.A. Centeno, and A.K. Patlolla, “Arsenic toxicity, mutagenesis and carcinogenesis-a health risk assessment and management approach,” Mol Cell Biochem, vol. 255, pp. 47–55, 2004.
40. J.A. Centeno, P.B. Tchounwou, A.K. Patlolla, F.G. Mullick, L. Murakat, E. Meza, H. Gibb, D. Longfellow, and C.G. Yedjou, “Environmental pathology and health effects of arsenic poisoning: a critical review,” In: Naidu R, Smith E, Smith J, Bhattacharya P Eds, Managing arsenic in the environment: from soil to human health. CSIRO, Adelaide, 2005.
41. R.A. Goyer, “Toxic effects of metals,” In: Klaassen CD Ed, Cassarett and Doull’s toxicology: the basic science of poisons. McGraw-Hill, New York, NY, 2001, pp 811–867.
42. M.F. Hughes, “Arsenic toxicity and potential mechanisms of action,” Toxicol Lett, vol. 133, pp. 1–16, 2002.
43. D.N. Wilson, “Cadmium-market trends and influences,” In: Cadmium association Ed, Cadmium 87, Proceedings of the 6th International Cadmium Conference, London, 1988, pp 9–16.
44. ATSDR, Draft toxicological profile for cadmium. Agency for Toxic Substances and Disease Registry, Atlanta, GA, 2008.
45. S. Satarug, J.R. Baker, S. Urbenjapol, M. Haswell-Elkins, P.E. Reilly, D.J. Williams, and M.R. Moore, “A global perspective on cadmium pollution and toxicity in non-occupationally exposed population,” Toxicol Lett, vol. 137, pp. 65–83, 2003.
46. R.C. Baselt, and R.H. Cravey, “Disposition of toxic drugs and chemicals,” in man, 4th ed, Year Book Medical Publishers, Chicago, IL, 1995, pp 105–107.
47. R.C. Baselt, “Disposition of toxic drugs and chemicals,” in man, 5th ed. Chemical Toxicology Institute, Foster City, CA, 2000.
48. R.L. Singhal, Z. Merali, P.D. Hrdina, “Aspects of the biochemical toxicology of cadmium,” Fed Proc, vol. 35, pp. 75–80, 1976.
49. M.P. Waalkes, “Cadmium and carcinogenesis,” Berthan G ed. Handbook on metal–ligand interactions of biological fluids, vol 2. Dekker, New York, NY, 1995, pp 471–482.
50. M.P. Waalkes, and R.R. Misra, “Cadmium carcinogenicity and genotoxicity,” Chang LW, Magos L, Suzuli T ed. Toxicology of metals. CRC, Boca Raton, FL, 1996, pp 231–243.
51. M.P. Waalkes, and S. Rehm, “Carcinogenicity of oral cadmium in the male Wistar (WF/NCr). Rat: effect of chronic dietary zinc deficiency,” FundamApplToxicol, vol. 19, pp. 512–520, 1992.
52. J. Landolph, “Molecular mechanisms of transformation of CH3/10T1/2C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds,” Environ Health Perspect, vol. 102, pp. 119–125, 1994.
53. J.A. Jacobs, S.M. Testa, “Overview of chromium (VI),” in the environment: background and history: Guertin J, Jacobs JA, Avakian CP ed, Chromium (VI). handbook. CRC, Boca Raton, FL, 2005, pp 1–22.
54. T. Norseth, “The carcinogenicity of chromium,” Environ Health Perspect, vol. 40, pp. 121–130, 1981.
55. X.F. Wang, M.L. Xing, Y. Shen, X. Zhu, L.H. Xu, “Oral administration of Cr(VI). induced oxidative stress, DNA damage and apoptotic cell death in mice,” Toxicology, vol. 228, pp. 16–23, 2006.
56. WHO/IPCS, Environmental health criteria 61: chromium. World Health Organization, Geneva, 1988.
57. P.H. Connett, K.E. Wetterhahn, “Metabolism of carcinogenic chromate by cellular constituents,” Struct Bond, vol. 54, pp. 93–24, 1983.
58. E, Kim, and K.J. Na, “Nephrotoxicity of sodium dichromate depending on the route of administration,” Arch Toxicol, vol. 65, pp. 537–541, 1991.
59. M. Gumbleton, and P.J. Nicholls, “Dose-response and time-response biochemical and histological study of potassium dichromate-induced nephrotoxicity in the rat,” Food ChemToxicol, vol. 26, pp. 37–44, 1988.
60. D. Bagchi, E.A. Hassoun, M. Bagchi, D. Muldoon, and S.J. Stohs, “Oxidative stress induced by chronic administration of sodium dichromate (Cr-VI). to rats,” Comp BiochemPhysiol, vol. 110, pp. 281–287, 1995.
61. D. Bagchi, P.J. Vuchetich, M. Bagchi, E.A. Hassoun, M.X. Tran, L. Tang, and S.J. Stohs, “Induction of oxidative stress by chronic administration of sodium dichromate (chromium VI). and cadmium chloride (cadmium II). to rats,” Free RadicBiol Med, vol. 22, pp. 471–478, 1997.
62. S.S. Wise, A.L. Holmes, M.E. Ketterer, W.J. Hartsock, E. Fomchenko, S.P. Katsifis, W.D. Thompson, and J.P. Wise, “Chromium is the proximate clastogenic species for lead chromateinducedclastogenicity in human bronchial cells,” Mutat Res, vol. 560, pp. 79–8, 2004.
63. H. Xie, S.S. Wise, A.L. Holmes, B. Xu, T. Wakeman, S.C. Pelsue, N.P. Singh, and J.P. Wise, “Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells,” Mutat Res, vol. 586, pp. 160–172, 2005.
64. C.G. Yedjou, and P.B. Tchounwou, “Oxidative stress in human leukemia cells (HL-60), human liver carcinoma cells (HepG2). and human Jerkat-T cells exposed to arsenic trioxide,” Metal Ions Biol Med, vol. 9, pp. 298–303, 2006.

Keywords
Exposure, Metal, Radiations, Pesticides, Toxicity, Genotoxic effects.