Neuronal Cells as an Ideal Model for Neurodegenerative Diseases.

International Journal of Biotech Trends and Technology (IJBTT)
© 2016 by IJBTT Journal
Volume - 6 Issue - 4                          
Year of Publication : 2016
Authors : Pallav Kaushik Deshpande, Ragini Gothalwal
DOI :  10.14445/22490183/IJBTT-V19P606


Pallav Kaushik Deshpande, Ragini Gothalwal "Neuronal Cells as an Ideal Model for Neurodegenerative Diseases.", International Journal of Biotech Trends and Technology (IJBTT), V6(4): 26-33 Oct - Dec 2016, Published by Seventh Sense Research Group.


Neurodegenerative diseases are pathological conditions that have an insidious onset and chronic progression. Different models have been established to study these diseases in order to understand their underlying mechanisms and to investigate new therapeutic strategies. Although various in vivo models are currently in use, in vitro models might provide important insights about the pathogenesis of these disorders and represent an interesting approach for the screening of potential pharmacological agents. In vitro models of these pathological conditions offer advantages over in vivo models in several aspects. First, it is possible to study the role of isolated cells of one particular type in an environment that simulates the disease and to investigate mechanisms of a possible deleterious or protective role of specific molecules and compounds. Second, screening for potential actions of drugs is also facilitated. Primary midbrain dopaminergic neurons are suitable to study dopaminergic cell survival and neurite retraction as well as regeneration. Usually, embryonic midbrain neurons from embryonic day 14 to 18 (E14-18) are ideal to culture initiation. A high yield of dopaminergic neurons can be obtained, which can be exposed to various neurodegenerative stimuli. In vitro models of neurodegenerative processes can provide important clues about mechanisms of the diseases and potential pharmacological targets.


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Neurodegenerative disease, Neuronal cells, Dopaminergic, Pharmaceutical targets.