G6PD deficiency: Study among 256 blood donors recruited at the blood transfusion center in Niamey

	International Journal of Biotech Trends and Technology (IJBTT)
	© 2016 by IJBTT Journal
	Volume - 6 Issue - 2
	Year of Publication : 2016
	Authors : Daouda Alhousseini, Mounkaila Boutchi, Maïguizo Seydou, Moumouni Sina Abdramane, Sanogo Ibrahim

Citation

Daouda Alhousseini, Mounkaila Boutchi, Maïguizo Seydou, Moumouni Sina Abdramane, Sanogo Ibrahim "G6PD deficiency: Study among 256 blood donors recruited at the blood transfusion center in Niamey", International Journal of Biotech Trends and Technology (IJBTT), V6(2): 1-4 Apr - Jun 2016, Published by Seventh Sense Research Group.

Abstract

Glucose 6-Phosphate Dehydrogenase Deficiency (G6PD) is an inherited enzymopathy which is characterized by acute or chronic hemolysis attacks triggered by oxidative stress during infections, contact with chemical, during medication or foods. In a context of nutritional anemia and/or parasitic diseases involving pregnancy or major sickle cell crises, the presence of this enzymopathy poses additional challenges to the blood transfusion. To determine the prevalence of G6PD deficiency in Niamey, we undertook to conduct a prospective study in 256 blood donors at the National Blood Transfusion Center. G6PD intra erythrocytic was determined by spectrophotometry on the hemolysate of washed red blood cells. Blood donors aged 18-65 years, having satisfied prior medical consultation and which have a greater or equal hemoglobin to 12 g/dl were selected as part of this study. The average age of donors was 32 years old. The deficit is estimated at 15.7%, including 9.7% of the total deficit to 6% partial deficit. Subjects deficient male G6PD accounted for 87.5% against 12.5% for the female sex. The average activity of G6PD was 2.9 ± 0.4 IU/g Hb in deficient subjects against 11.7 ± 0.3 IU/g Hb for the non deficient. Means Hb of normal subjects, partially and totally deficient subjects were respectively 15.3 g/dl, 14.8 g/dl and 14.3 g/dl (P = 0.7). The family donation represented 61.5% and the donor parental consanguinity rate was 21%. As G6PD deficiency was higher in the donor population, targeted screening blood bags could be considered when they are intended for certain categories of patients.

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Keywords
Blood donors, G6PD deficiency, hemoglobin, Niamey.