Neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency in Niamey
||International Journal of Biotech Trends and Technology (IJBTT)|
|© 2016 by IJBTT Journal|
|Volume - 6 Issue - 1
|Year of Publication : 2016|
|Authors : Mounkaila B, Daouda A, Garba Rm, Aridouane D|
Mounkaila B, Daouda A, Garba Rm, Aridouane D "Neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency in Niamey", International Journal of Biotech Trends and Technology (IJBTT), V6(1): 12-14 Jan - Mar 2016, Published by Seventh Sense Research Group.
G6PD deficiency is a hereditary enzymopathy linked recessive X which can cause chronic or acute hemolytic anemia with severe jaundice risks. Knowledge of this profile very early at birth will have the effect of reducing morbidity and neonatal mortality. The objective of this study was to determine the prevalence of this deficiency in newborns in Niamey through a cross-sectional descriptive study. G6PD intra erythrocyte of umbilical cord blood was measured by spectrophotometry at the same time as the intra erythrocyte ASAT that was used to estimate the age of the erythrocytes. Two hundred four neonates including 113 male (55.5%) and 91 female (44.5%) were enrolled. The overall prevalence of deficit was estimated at 11.80%. The partial deficit represented 10.3% against 1.5% for the total deficit. The G6PD activity was on average 4.11 ± 0,4UI / g Hb whereas it was 1.7 ± 0.2 U / g Hb in newborns totally deficit and 24, 30 ± 1.2 U / g Hb in newborns without G6PD deficiency. The report G6PD / ASAT in newborns fully and partially deficit were 0.30 and 0.80 respectively. Hb levels in all three groups have no significant difference. The high prevalence of G6PD deficiency in the newborn population justifies the establishment of early screening at birth.
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G6PD deficiency, neonatal, umbilical cord blood, Niamey.