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International Journal of Biotech Trends and Technology (IJBTT) |  |
| © 2023 by IJBTT Journal | ||
| Volume - 13 Issue - 2 | ||
| Year of Publication : 2023 | ||
| Authors : Amruta Sonawane, Atharva Hastekar, Amit Kakad, M.R.N Shaikh, Roma Sharma | ||
| DOI : 10.14445/22490183/IJBTT-V13I2P602 |
How to Cite?
"Herbal Bio-Actives: A Key for Bioavailability Enhancement of Drugs" International Journal of Biotech Trends and Technology vol. 13, no. 2, pp. 8-19, 2023. Crossref, https://doi.org/10.14445/22490183/IJBTT-V13I2P602
Abstract
Background: In recent years, there has been a major interest and medical need for the enhancement of the bioavailability of several drugs which are poorly bioavailable. Poorly bioavailable drugs remain sub-therapeutic because a considerable portion of a dose never enters the plasma or exerts its pharmacological action unless and until very large doses are delivered. bioenhancers play a key role in raising the bioavailability and efficacy of a variety of pharmacological drugs at minimal doses. Main Body: The present work’s main goal is to review bioenhancers, their modes of action, characteristics, classification, overview, and formulation in the market of bioenhancers. Importance of Fulvic Acid, Gelucire, Naringin, Esters of gallic acid, Cumin, Ginger, Caraway, Piperine, Sinomenine, Genistein, Lysergol, Cow urine distillate, Nitrile glycoside, Glycyrrhizin, Capmul, Gokhru and, Aloe vera gel as bioenhancers. Conclusion: The various bioenhancers, emphasizing their distinct modes of actions, applications, and their safe dose and drugs bio-enhanced by them. It also focuses on the most recent breakthrough notion of using bio-enhancers to improve the bioavailability/bio-efficacy of low-bioavailability medications, metals, nutraceuticals, and vitamins through various techniques. Therefore, Extensive research on these bio-enhancers should be carried out so that they can be utilized in drug formulations.
Keywords
Bioenhancer, Bioavailability, Bio-efficacy, Herbal, Bio-actives.
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