Synergistic Role of Renin-Angiotensin System and Dyslipidemia in Diabetic Kidney Disease: A Mini Review

IJCOT-book-cover International Journal of Biotech Trends and Technology  (IJBTT)          
 
© 2023 by IJBTT Journal
Volume - 13 Issue - 1
Year of Publication : 2023
Authors : Umme Najiya Mahwish, Swetha Ch, Babi Heera, K. Rudrama Devi, Sree Bhushan Raju, Parveen Jahan
DOI :   10.14445/22490183/IJBTT-V13I1P602

How to Cite?

Umme Najiya Mahwish, Swetha Ch, Babi Heera, K. Rudrama Devi, Sree Bhushan Raju, Parveen Jahan "Synergistic Role of Renin-Angiotensin System and Dyslipidemia in Diabetic Kidney Disease: A Mini Review," International Journal of Biotech Trends and Technology  vol. 13, no. 1, pp. 7-15, 2023. Crossref, https://doi.org/10.14445/22490183/IJBTT-V13I1P602 

Abstract

Renin-angiotensin system (RAS) is a well-documented active mediator in progressive diabetic kidney disease (DKD). Ancillary to hyperglycemia association with dyslipidemia appears to impact the initiation and progression of renal injury in diabetes, giving a link between plasma lipoproteins and angiotensin II in the causation of renal injury under a hyperglycemic setup. Activation of local RAS convoluted in hyperlipidemia-mediated renal injury results in the extracellular matrix deposition in the tubular interstitium, suggesting that the major effector peptide (Ang II) of the RAS pathway and lipoproteins does not act independently but acts synergistically facilitating the progression of chronic kidney disease. Appreciating the relationship between Angiotensin Converting Enzyme (ACE) Insertion/Deletion (I/D) genotypes or any other ACE gene polymorphism and dyslipidemia with DKD opens up the scope for early recognition of diabetic patients with a high risk of DKD. Systematic in-depth observational and ethnic population studies considering ACE Inhibitors and anti-lipid drugs in relation to ACE genotypes are warranted to help understand the role of the ACE gene that appears to be a major contributor to the complex mechanism involved and the environment in the form of lifestyle in diabetic kidney disease complication.

Keywords

Renin-angiotensin system, Diabetic kidney disease, Hyperglycemia, Dyslipidemia, ACE gene polymorphism.

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