IJBTT

	International Journal of Biotech Trends and Technology  (IJBTT)
	© 2022 by IJBTT Journal
	Volume - 12 Issue - 3
	Year of Publication : 2022
	Authors : Jaiswal Kailash, Gothalwal Ragini, Yadav AS
	DOI :   10.14445/22490183/IJBTT-V12I3P603

How to Cite?

Jaiswal Kailash, Gothalwal Ragini, Yadav AS "Microcystin-LR Exhibit Cytotoxicity in Myeloma Sp2/01 Cancer Cell Line and Emerging as a Potential Anticancer Therapeutics" International Journal of Biotech Trends and Technology  vol. 12, no. 3, pp. 18-30, 2022. Crossref, https://doi.org/10.14445/22490183/IJBTT-V12I3P603 

Abstract

Microcystis aeruginosa, widely distributed, produce the bioactive compound microcystin toxin, which induces liver cancer and poses many severe threats to human health. Microcystis aeruginosa produces secondary metabolites with broad pharmaceutical importance and biological activities in anticancer, antibacterial, antiviral and protease inhibition activities. New drug discovery is complicated, expensive, time-consuming and challenging for human life when treating disease, the new cutting-edge technology and the rapid growth of advanced computing bioinformatics tools for new drug identification and characterization, including anticancer therapies. In this work, the Microcystis aeruginosa strain was isolated from different regions of central India; the strain identification was based on morphological properties and mcyA, mcyB gene sequence analysis. The Cytotoxicity assayed against the myeloma Sp2/01 cancer cell line, 50 µl of Microcystin-LR (MC-LR) at 48 h; a marked cytotoxic effect was only detected after exposure to the highest toxin concentration (200 µl), and the MC-LR showed strong inhibition with an IC50 value of 29-39 μl. According to the findings, the MC-LR is a promising potential therapeutic anticancer compound, providing new leads for the characterization and development of a novel anticancer drug.

Keywords

Anticancer, Microcystis aeruginosa, Cyanotheraputics, Hepatic cancer, Therapeutics, Genetic diversity.

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