IJBTT

	International Journal of Biotech Trends and Technology (IJBTT)
	© 2021 by IJBTT Journal
	Volume - 11 Issue - 4
	Year of Publication : 2021
	Authors : Pacôme Kouadio N’Go, Eric-Kevin Gbouhoury Bolou, Habib Omar Doumbia, Romaric Taki Yian, Antoine Némé Tako
	DOI :  10.14445/22490183/IJBTT-V11I4P602

Citation

MLA Style:Pacôme Kouadio N’Go, et al."Long-Lasting Cognitive-Affective Disorders Induced In Rats After Neonatal Exposure to LPS: The Neuroprotective Effects of Costus afer (Costaceae) Extract" International Journal of Biotech Trends and Technology 11.4 (2021): 7-14.

APA Style:Pacôme Kouadio N’Go, Eric-Kevin Gbouhoury Bolou, Habib Omar Doumbia, Romaric Taki Yian, Antoine Némé Tako(2021). Long-Lasting Cognitive-Affective Disorders Induced In Rats After Neonatal Exposure to LPS: The Neuroprotective Effects of Costus afer (Costaceae) Extract. International Journal of Biotech Trends and Technology, 11(4), 7-14.

Abstract

We aimed to assess the possible effects of hydroethanolic extract of Costus afer on long-lasting cognitive and affective disorders due to an early life neuroinflammation induction with lipopolysaccharide (LPS). At postnatal day 14(PND 14), neonate rats were exposed with single dose to LPS (250 µg/kg, i.p.), and 24 h later treated with either Costus afer extract (400 mg/kg, p.o.) or a reference drug melatonin (10 mg/kg, i.p) for two weeks. At PND 90, cognitive abilities as well as affective status were examined, followed by the biomarkers assay in the brain. As results, the Costus afer extract significantly prevented the neonatal exposure to LPS-induced recognition and working spatial memory deficits in adulthood. Furthermore, the extract of Costus afer attenuated anxiety- and depressive-like behaviors caused by the LPS. Otherwise, the treatment with Costus afer extract significantly inhibited the lipide membrane peroxidation through a reduction of malondialdehyde (MDA) level as well as the decrease of nitric oxide (NO) content, mainly in the hippocampus. Overall, the treatment with Costus afer extract seems to be a bit more efficient than that of the melatonin. Our findings suggest that Costus afer possesses some neuroprotective effects.
However, additional pharmacological approaches are needed before promising Costus afer as effective therapeutic

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Keywords
Anti-oxidative stress; cognitive-affective disorders; Costus afer; neonatal neuroinflammation