In silico Drug Designing and Phytochemicals prospect in Liver Cancer Therapeutics

 
 
International Journal of Biotech Trends and Technology (IJBTT)
 
© 2021 by IJBTT Journal
Volume - 11 Issue - 3                          
Year of Publication : 2021
Authors : Sneha Iyer, Reddy Om Sri Krishna, Vaishali Bisht, Apeksha Yadava
DOI :  10.14445/22490183/IJBTT-V11I3P605

Citation

MLA Style:Sneha Iyer, Reddy Om Sri Krishna, Vaishali Bisht, Apeksha Yadava  "In silico Drug Designing and Phytochemicals prospect in Liver Cancer Therapeutics" International Journal of Biotech Trends and Technology 11.3 (2021): 31-41.

APA Style:Sneha Iyer, Reddy Om Sri Krishna, Vaishali Bisht, Apeksha Yadava(2021). In silico Drug Designing and Phytochemicals prospect in Liver Cancer Therapeutics International Journal of Biotech Trends and Technology, 11(3), 31-41.

Abstract

Cancer is a major public health problem worldwide. Affecting people of all ages, cancer cuts through society, causing suffering on a global scale. According to the World Health Organization, cancer is responsible for one in six deaths, making it the second most common cause of death globally. Hepatocellular carcinoma (HCC) is the most frequent cause of all liver cancers and constitutes 90% of liver cancers globally. The mortality in HCC is very high; about 7 Lakhs of death due to HCC occur annually and has been estimated to be 3rd common cause of death due to cancers affecting humans. The increasing knowledge of molecular and tumor biology has notably changed cancer treatment paradigms during the past 15 years. Current primary cancer management treatments include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy, endocrine therapy, and immunotherapy. Despite the endeavors and achievements made in treating cancers during the past decades, resistance to classical chemotherapeutic agents and/or novel targeted drugs continues to be a major problem in cancer therapies. The drug discovery process is very complex and includes an interdisciplinary effort for designing effective and commercially feasible drugs. In pharmaceutical, natural medicine, as well as in other scientific research, computers play a very important role, even in the development of new compounds in the quest for better therapeutic agents. A combination of rational drug design and structural biology leads to the discovery of novel therapeutic agents. For this purpose, the Computer-aided drug design (CADD) Center works with collaboration between structure biologists, biophysicists, and computational scientists for the discovery of new chemical entities. CADD and bioinformatics tools in the field of phytochemicals provide benefits like cost-saving, time to market, in-sight knowledge of drug-receptor interactions, speed up drug discovery and development.

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Keywords
Liver Cancer, CADD, Phytochemicals, Natural medicine, Drug resistance.