FASN Gene And Its Role In Bovine Milk Production
 |
International Journal of Biotech Trends and Technology (IJBTT) |  |
| © 2021 by IJBTT Journal | ||
| Volume - 11 Issue - 1 |
||
| Year of Publication : 2021 | ||
| Authors : D.S.Kale, Jaya Singh, Y.B. Sathe, D.V.Patil | ||
| DOI : 10.14445/22490183/IJBTT-V11I1P604 |
Citation
MLA Style:D.S.Kale, Jaya Singh, Y.B. Sathe, D.V.Patil "FASN Gene And Its Role In Bovine Milk Production" International Journal of Biotech Trends and Technology 11.1 (2021): 20-25.
APA Style:D.S.Kale, Jaya Singh, Y.B. Sathe, D.V.Patil(2021). FASN Gene And Its Role In Bovine Milk Production. International Journal of Biotech Trends and Technology, 11(1), 20-25.
Abstract
FASN (Fatty Acid Synthase) is regarded as a candidate gene for milk production traits in cattle which is a multidomain enzyme complex and functions for the synthesis of palmitic acid through denovo lipogenesis. The current emphasis world over is to identify the genetic mechanisms behind the milk composition and milk production traits like fat synthesis for identification of genetic signatures behind economic traits and their use in the selection of quality animals of breeds. The high concentration of dietary monounsaturated and polyunsaturated fatty acids are found to be associated with low cholesterol and low-density lipoproteins level, which aids in decreasing the risk of several cardiovascular diseases. In view of this, the studies related to the identification of genetic variation within FASN candidate gene reported to be exhibiting significant SNPs related to milk composition and production traits need to be reviewed for understanding the identified significant genetic variants, effective techniques, its impact on its possible use as DNA marker for fat milk traits in selection and breeding decisions of cattle breed improvement.
References
[1] Jandal, J.M., Comparative Aspects of Goat and Sheep Milk. Small Ruminant Research, 22(2)(1996) 177–85.
[2] Koletzko, B., et al., Growth, Development and Differentiation: A Functional Food Science Approach. British Journal of Nutrition,. 80(S1)(1998) S5–45.
[3] Lock A.L., and D.E Bauman ., Modifying Milk Fat Composition of Dairy Cows to Enhance Fatty Acids Beneficial to Human Health. Lipids, 39(12)(2004) 1197–1206.
[4] Mele, M., et al., Stearoyl-Coenzyme a Desaturase Gene Polymorphism and Milk Fatty Acid Composition in Italian Holsteins. Journal of Dairy Science, 90(9)(2007) 4458–65.
[5] Kgwatalala, P.M., et al., Influence of Stearoyl-Coenzyme A Desaturase 1 Genotype and Stage of Lactation on Fatty Acid Composition of Canadian Jersey Cows. Journal of Dairy Science, 92(3)(2009) 1220–28.
[6] Krauss, R.M, Lipoprotein Subfractions, and Cardiovascular Disease Risk. Current Opinion in Lipidology, 2010. 21(4)(2010) 305–11.
[7] Bouwman, C.A., et al., Genome-Wide Association of Milk Fatty Acids in Dutch Dairy Cattle. BMC Genetics,. 12(43)(2011) 1-12.
[8] Roy, R., et al., Association of Polymorphisms in the Bovine FASN Gene with Milk-Fat Content. Animal Genetics, 37(3)(2006) 215–18.
[9] Schennink, A., et al., Effect of Polymorphisms in the FASN, OLR1, PPARGC1A, PRL and STAT5A Genes on Bovine Milk-Fat Composition. Animal Genetics, 40(6)(2009) 909–16.
[10] Bionaz, M. and J.J. Loor, Gene Networks Driving Bovine Milk Fat Synthesis during the Lactation Cycle. BMC Genomics, 9(366)(2008) 1–21.
[11] Bouwman, C.A., et al., Genomic Regions Associated with Bovine Milk Fatty Acids in Both Summer and Winter Milk Samples. BMC Genetics, 13(93)(2012) 2-13.
[12] Rahayu, A.P., et al., Association of Single Nucleotide Polymorphisms in the Fatty Acid Synthase, LOC514211, and Fat Mass and Obesity-Associated Genes with Milk Traits in Indonesian-Holstein Dairy Cattle. Veterinary World, 12(7)(2019) 1160–66.
[13] Amy, M.C., et al., Molecular Cloning of the Mammalian Fatty Acid Synthase Gene and Identification of the Promoter Region. Biochemical Journal, 271(3)(1990) 675–79.
[14] Jayakumar, A., et al., Isolation and Chromosomal Mapping of Genomic Clones Encoding the Human Fatty acid Synthase Gene. Genomics, 23(2)(1994) 420-424.
[15] Chirala, S.S., et al., Animal Fatty Acid Synthase: Functional Mapping and Cloning and Expression of the Domain I Constituent Activities. Proceedings of the National Academy of Sciences of the United States of America,. 94(11)(1997) 5588–93.
[16] Roy, R., et al., Assignment of the Fatty Acid Synthase (FASN) Gene to Bovine Chromosome 19 (19q22) by in Situ Hybridization and Confirmation by Somatic Cell Hybrid Mapping. Cytogenetics and Cell Genetics,. 93(2001)(1–2) 141–42.
[17] Chakravarty, B., et al., Human Fatty Acid Synthase: Structure and Substrate Selectivity of the Thioesterase Domain. Proceedings of the National Academy of Sciences of the United States of America, 101(44)(2004) 15567–72.
[18] Roy, R., et al., Genomic Structure and Alternative Transcript of Bovine Fatty Acid Synthase Gene (FASN): Comparative Analysis of the FASNgene between Monogastric and Ruminant Species. Cytogenetic and Genome Research., 111(1)(2005) 65–73.
[19] Maier, T., S. Jenni and B. Nenad, Architecture of Mammalian Fatty Acid Synthase at 4.5 å Resolution. Science, 311(5765)(2006). 1258–62.
[20] Gibson, D.M., E.B. Titchener, and S.J. Wakil, Studies on the Mechanism of Fatty Acid Synthesis V. Bicarbonate Requirement for the Synthesis of Long-Chain Fatty Acids. BBA - Biochimica et Biophysica Acta, 30(2)(1958) 376–83
[21] Alberts, W.A.., et al., Acyl-Carrier Protein. II. Intermediary Reactions of Fatty acid Synthesis. Biochemistry,. 3(10)(1964) 1563-72.
[22] Morris, C.A., et al., Fatty Acid Synthase Effects on Bovine Adipose Fat and Milk Fat. Mammalian Genome,. 18(1)(2007) 64–74.
[23] Ordovás, L. et al., The g.763G>C SNP of the Bovine FASN Gene Affects Its Promoter Activity via Sp-Mediated Regulation: Implications for the Bovine Lactating Mammary Gland. Physiological Genomics,. 34(2)(2008) 144–48.
[24] Nafikov, R., et al., Effects of A17924G Genotypes Associated with Thioesterase Domain of Fatty Acid Synthase and K232A Genotypes of Diacylglycerol Acyltransferase-1 on Milk Fatty Acid Composition in Holstein Dairy Cows. Animal Industry Report, 2009. 655(1). 56., ASL R2433.
[25] Schennik, A., et al., Effect of Polymorphism in the FASN, OLR1, PPARGC1A, PRL and STAT5 genes on bovine milk-fat composition. Animal Genetics,. 40(6)(2009) 909-916.
[26] Wu, X., et al., Genetic diversity analysis of FASN gene and its correlation with milk performance in Southern Chinese Holstein. Chinese Journal of Animal Science,. 1(1)(2010) 1-4.
[27] Kaneda, M., et al., Allele frequnecies of gene polymorphism related to economic traits in Bos indicus and Bos taurus cattle breeds. Animal Science Journal, 82(6)(2011) 717-721.
[28] Matsumoto, H., et al., Identification of SNPs in the FASN Gene and Their Effect on Fatty Acid Milk Composition in Holstein Cattle. Livestock Science, 144(3)(2012) 281–84.
[29] Inostroza, B Karla., Erick S Scheuermann and Nestor A Sepulveda, Stearoyl CoA desaturase and Fatty acid synthase gene polymorphism and milk fatty acid composition in Chilean Black Frieian cows. Rev Colomb Cienc Pecu., 26(4)(2013) 263-269.
[30] Ciecierska, D., et al., The influence of Fatty Acid Synthase Polymorphism on milk production traits in Polish Holstein- Friesian Cattle. The Journal of Animal and Plant Sciences, 23(2)(2013) 376-379.
[31] Ishii, A., et al., Genome-wide association study for fatty acid composition in Japanese Black cattle. Animal Science Journal, 84(10)(2013) 675-82.
[32] Sanz, A., et al., 5’ Cis-regulatory polymorphisms in candidate genes in Bos taurus and Bos indicus. Livestock Science, 157(1)(2013) 88–92.
[33] YanNan, M., et al., Correlation between PCR-SSCP polymorphism of part FASN gene sequence and milk traits in Chinese Holstein cattle. Journal of Northwest A & F university- Natural Science Edition,. 41(12)(2013)1-6.
[34] Alim, M.A., et al., Effect of FASN gene on milk yield and milk composition in the Chinese Holstein dairy population. Animal Genetics, 45(1)(2013) 111-3.
[35] Fontanesi, L., et al., A candidate gene association study for nine economically important traits in Italian Holstein Cattle. Animal Genetics, 45(4)(2014) 576-580.
[36] Oztabak, K., et al., FASN gene polymorphism in Indigenous Cattle breeds of Turkey. Folia Biologica (Kraków),. 62(1)(2014) 29-35.
[37] Vohra, V., et al., Polymorphism in Exon 40 of FASN Gene in Lesser-known Buffalo Breeds of India. Journal of Animal Research,. 5(2)(2015) 325-328.
[38] Li, C., et al., Genetic Effects of FASN, PPARGC1A, ABCG2 and IGF1 Revealing the Association with Milk Fatty Acids in a Chinese Holstein Cattle Population Based on a Post Genome-Wide Association Study. BMC Genetics,. 17(1)(2016) 110.
[39] Kumar, M., et al., SNP identification in thioesterase domain of fatty acid synthase gene in Murrah Buffalo. The Journal of Animal and Plant Sciences, 26(6)(2016) 1828-1832.
[40] Kumar, M., et al., Influence of FASN gene polymorphism on milk production and its composition traits in Murrah buffaloes. Indian Journal of Animal Research,. 51(4)(2017) 640-643.
[41] Mauric, M., et al., Effects of Different Variants of the FASN Gene on Production Performance and Milk Fatty Acid Composition in Holstein × Simmental Dairy Cows. Veterinarni Medicina,. 64(03)(2019) 101–108.
[42] Citek, J., et al., Gene polymorphisms influencing on yield, composition and technological properties of milk from Czech Simmental and Holstein cows. Asian- Australasian Journal of Animal Sciences, 34(1)(2020) 2-11.
[43] Wang, Q., and Bovenhuis H, Combined use of milk infrared spectra and genotypes can improve prediction of milk fat composition. Journal of Dairy Science,.103(3)(2020) 2514-2522.
Keywords
FASN, DNA Markers, Milk traits, and Bovine