TCR-clonotyping-based Analysis of a Frenemy —Public T Cells

International Journal of Biotech Trends and Technology (IJBTT)
© 2015 by IJBTT Journal
Volume - 5 Issue - 1                          
Year of Publication : 2015
Authors : Huihui Qi, Yang Li, Liguang Sun


Huihui Qi, Yang Li, Liguang Sun " TCR-clonotyping-based Analysis of a Frenemy —Public T Cells ", International Journal of Biotech Trends and Technology (IJBTT), V5(1):33-37 Jan - Mar 2015, Published by Seventh Sense Research Group.


Public T cells are characterized by a T-cell population bearing identical T-cell receptor (TCR) amino acid sequences in a majority of individuals. However, due to their out-of-balance production, they may serve as both "friend" and "enemy", i.e. a frenemy in many physiological and pathological activities. Thanks to the development of advanced TCR-clonotyping methods, such as next generation sequencing (NGS), we can gain a better understanding of public T-cell responses. In this review, we commenced with the underlying mechanisms of public TCR-production, and then discussed some researches that have been successfully utilized as a new method for the study of the CDR3 regions of the public and private TCRs, and we further explored the merits and demerits of the public T cells in different diseases. Finally, we discussed the current challenges and future hot focuses.


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public T cells, TCR clonotyping, public TCR, private TCR, NGS.