International Journal of Biotech Trends and Technology (IJBTT)
 
© 2021 by IJBTT Journal
Volume - 11 Issue - 3                          
Year of Publication : 2021
Authors : Muhammad Azeem, Tanzeela Rehman, Muhammad Faiq, Uzma Qaisar
DOI :  10.14445/22490183/IJBTT-V11I3P607

Citation

MLA Style:Dr. Nagham Mahmood Aljamali, Zahraa Abdul Kareem makki, Enas Raheem Al_kidsawey  "Review in Mutated Strains of Corona Virus" International Journal of Biotech Trends and Technology 11.3 (2021): 51-57.

APA Style:Dr. Nagham Mahmood Aljamali, Zahraa Abdul Kareem makki, Enas Raheem Al_kidsawey(2021). Review in Mutated Strains of Corona VirusInternational Journal of Biotech Trends and Technology, 11(3), 51-57.

Abstract

The recent review conversed about mutated strain., The new mutated strains of the Corona virus are the mutated strain of Covid 19, the strain - also known as "variant" - is a version of the virus that includes a group of mutations, which means that each mutated strain includes a group of mutations. A mutation is a change in the arrangement of the genetic material in the virus, and some of these mutations may not leave a trace in the virus, but some of them may affect its ability to transmit and infection. There have been previous mutations recorded for the Corona virus, including the English, Brazilian and South African strains., Pfizer has designed a suitcase-sized container that “keeps doses at minus 70 for 10 days, holding 1,000 to 5,000 doses, and needs to be filled with fresh, dry ice within 24 hours, then tracked via GPS until it reaches the desired location, with Not to open it more than twice a day, and for one minute each time,” according to what was quoted today by leaked documents from Pfizer yesterday, and its information indicates that vaccination will not be an easy process, but rather difficult for obstacles, especially since the effectiveness of the vaccine begins 28 days after vaccination.

References

[1] Alwan A ،Mahjour J ،Memish ZA, Novel coronavirus infection: time to stay ahead of the curve. Eastern Mediterranean Health Journal.,19 Suppl, 12(4)1 (2013) S3–4. PMID 23888787., Available at : http://www.xinhuanet.com/english/2021-02/02/c_139716241.htm
[2] Laude H ،Rasschaert D ،Delmas B ،Godet M ،Gelfi J ،Charley B . Molecular biology of transmissible gastroenteritis virus. Veterinary Microbiology., 23 (1–4) (1999) 147–54. PMID 2169670 . doi:10.1016/0378-1135(90)90144-K., Available at : https://www.voanews.com/covid-19-pandemic/malawi-sticks-astrazeneca-despite-concerns-over-efficacy
[3] Nagham Mahmood Aljamali, Enas Raheem Al_kidsawey, Zahraa Abdul Kareem Makki. Review in Stages of Development of Corona Virus Vaccines. International Journal of Analytical and Applied Chemistry. 7(1) (2021) 17–25p.
[4] Nagham Mahmood Aljamali, Farah Wadai El-Taei, Asaed H Enad ., Survey in Forms of Corona Vaccines Licensed by Global Health Organizations, Journal of Pharma and Drug Regulatory Affairs., 3(2) (2021) 55-62.
[5] Sola I ،Alonso S ،Zúñiga S ،Balasch M ،Plana-Durán J ،Enjuanes L, Engineering the transmissible gastroenteritis virus genome as an expression vector inducing lactogenic immunity. Journal of Virology, 77 (7) (2003) 4357–69. PMC 150661. PMID 12634392. doi:10.1128/JVI.77.7.4357-4369.2003.
[6] Tajima M . Morphology of transmissible gastroenteritis virus of pigs. A possible member of coronaviruses. Brief report. Archiv für die Gesamte Virusforschung., 29 (1) (1970) 105–8 . PMID 4195092 doi:10.1007/BF01253886.
[7] Liu P ،Shi L ،Zhang W ،He J ،Liu C ،Zhao C ،Kong S ،Loo JF ،Gu D ،Hu L., Prevalence and genetic diversity analysis of human coronaviruses among cross-border children. Virology Journal, 14 (1) (2019) 230. PMC 5700739 PMID 29166910. doi:10.1186/s12985-017-0896-0.
[8] Forgie S ،Marrie TJ, Healthcare-associated atypical pneumonia". Seminars in Respiratory and Critical Care Medicine, 30 (1) (2009) 67–85. PMID 19199189. doi:10.1055/s-0028-1119811.
[9] Aseel Mahmood Jawad, Nagham Mahmood Aljamali, Saher Mahmood Jwad. Development and Preparation of ciprofloxacin Drug Derivatives for Treatment of Microbial Contamination in Hospitals and Environment, Indian Journal of Forensic Medicine & Toxicology, 14 (2020) (2) 1115-1122.
[10] Imad Kareem Alwan Alsabri, Hasaneen Kudhair Abdullabass, Nagham Mahmood Aljamali., Invention of (Gluta.Sulfazane-Cefixime) Compounds as Inhibitors of Cancerous Tumors., Journal of Cardiovascular Disease Research, 11(2)(2020).
[11] Nagham Mahmood Aljamali, Imad Kareem Alwan Alsabri, Aseel Mahmood Jawad, Muayad Baqer Mohammed Alfahham, Hanan Ali Hussein. Scientific Study:(Solutions and Recommendations to avoid the Spread of Corona Virus Covid 19 in Iraq) , Forefront Journal of Engineering &Technology, 2(4) (2020) 13-22.
[12] Nagham Mahmood Aljamali ,Kawther Mejbel Hussein., Review on Benefits and Harms of Nutritional Supplements on Health ., Journal of Pharma and Drug Regulatory Affairs., 3(1) (2021) 42-49.
[13] Alexander E Gorbalenya ،Susan C. Baker ،Christian Drosten ،Bart L. Haagmans ,Benjamin W. Neuman ., The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 , Nature Microbiology, 544(5) (2019) 536, https://dx.doi.org/10.1038/S41564-020-0695-Z — https://pubmed.ncbi. nlm.nih.gov/32123347
[14] Nagham Mahmood Aljamali, Aseel Mahmood Jawad, Imad Kareem Alwan Alsabri., Public Health in Hospitals, 1 First Edition, (2020), Eliva Press ,ISBN: 9798636352129 .
[15] Liu P, Shi L, Zhang W, He J, Liu C, Zhao C, et al. Prevalence and genetic diversity analysis of human coronaviruses among cross-border children. Virology Journal. 14 (1)(2017)230. doi:10.1186/s12985-017-0896-0. PMC 5700739. PMID 29166910.
[16] Aseel Mahmood Jawad, Nagham Mahmood Aljamali., Innovation, Preparation of Cephalexin Drug Derivatives and Studying of (Toxicity & Resistance of Infection), International Journal of Psychosocial Rehabilitation, 24(04) (2020) 3754-3767 .
[17] Gorbalenya AE. Severe acute respiratory syndrome-related coronavirus – The species and its viruses, a statement of the Coronavirus Study Group. bioRxiv, 02(07) (2020). 937862. doi:10.1101/2020 .02.07.937862.
[18] Huynh J, Li S, Yount B, Smith A, Sturges L, Olsen JC. Evidence supporting a zoonotic origin of human coronavirus strain NL63. Journal of Virology, 86 (23) (2012) 12816–25. doi:10.1128/JVI.00906-12 . PMC 3497669 . PMID 22993147.
[19] Nagham Mahmood Aljamali., Abdullabass, H. K., Jawad, A. M., Alfatlawi, I. O., & Jawd, S. M. Review on Types of Automatic Sterilization Systems in Hospitals. International Journal of Industrial Biotechnology and Biomaterials, 6(1) (2020) 15-21.
[20] Nagham Mahmood Aljamali., A M Jawad., Alfatlawi, I. O., Saher Mahmood Jawd. (2020). Review on Hospital Bacteria (Causes, Infections, Prevention). Infection, 11(2020) 16.
[21] Vijaykrishna D, Smith GJ, Zhang JX, Peiris JS, Chen H, Guan Y. Evolutionary insights into the ecology of coronaviruses". Journal of Virology. 81(8) (2007) 4012–20. doi:10.1128/jvi.02605-06. PMC 1866124 . PMID 17267506.
[22] Nagham Mahmood Aljamali , Hasaneen Kudhair Abdullabass, Imad Kareem Alwan Alsabri, Nemah Sahib Mohammed Husien, Ahmed Adnan Abdul Hussein, Wisam Hassan Ali Alfartosi., Review on Reasons for The Spread of Corona Virus., International Journal of Cell Biology and Cellular Process, 6(1)(2020).
[23] Nagham Mahmood Aljamali .,Imad Kareem Alwan A., Hasaneen Kudhair Abdullabass., Aseel Mahmood Jawad .,Intisar O Alfatlawi ., Ahmed Adnan Abdul H .,Manar Ghyath Abd Almutalib A , Review in SARS-Corona Virus (Types, Infection, Diagnosis, Chemical Antiseptics for this Virus), Journal of Science and Technology, 05(3) (2020) 111-224.
[24] Nagham Mahmood Aljamali ,Muhsin Mohammed Al Najim (2020). Review in Hospital-Acquired Infection. International Journal of Advances in Engineering Research. 20(3) (2020) 7-20.
[25] Nagham Mahmood Aljamali., Aseel Mahmood Jawd.,Anaam Jawad Alabbasy, Layla Ali M S. A Literature Review on Types of Contamination (Biological, Chemical, Medical). International Journal of International Journal of Green Chemistry .; 5 (1) (2019) 7–14. [26] Gouilh MA, Puechmaille SJ, Gonzalez JP, Teeling E, Kittayapong P, Manuguerra JC. SARS-Coronavirus ancestor's foot-prints in South-East Asian bat colonies and the refuge theory. Infection, Genetics and Evolution. 11 (7) (2011) 1690–702. doi:10.1016/j.meegid.2011.06.021 PMID 21763784.
[27] Cui J, Han N, Streicker D, Li G, Tang X, Shi Z, et al. Evolutionary relationships between bat coronaviruses and their hosts. Emerging Infectious Diseases. 13 (10) (2007) 1526–32. doi:10. 3201/eid1310.070448 . PMC 2851503. PMID 18258002.
[28] Crossley BM, Mock RE, Callison SA, Hietala SK, Identification and characterization of a novel alpaca respiratory coronavirus most closely related to the human coronavirus 229E. Viruses, 4 (12) (2012) 3689–700, doi:10.3390/v4123689. PMC 3528286. PMID 23235471.
[29] Forgie S, Marrie TJ. Healthcare-associated atypical pneumonia. Seminars in Respiratory and Critical Care Medicine. 30 (1) (2009) 67–85. doi:10.1055/s-0028-1119811. PMID 19199189.
[30] Corman VM, Muth D, Niemeyer D, Drosten C. Hosts and Sources of Endemic Human Coronaviruses. Advances in Virus Research. 100 (2018) 163–88. doi:10.1016/bs.aivir.2018.01.001. ISBN 978-0-12-815201-0 . PMID 29551135.
[31] Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 395 (10223) (2020) 470–473. doi:10.1016/S0140-6736(20)30185-9. PMID 31986257.
[32] Lau EH, Hsiung CA, Cowling BJ, Chen CH, Ho LM, Tsang T, et al. A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan. BMC Infectious Diseases. 10(50) (2010). doi:10.1186/1471-2334-100. PMC 2846944. PMID 20205928.
[33] Karlberg J, Chong DS, Lai WY. Do men have a higher case fatality rate of severe acute respiratory syndrome than women do?. American Journal of Epidemiology. 159 (3) (2004) 229–31. doi:10.109 3/aje/ kwh056. PMID 14742282.
[34] Oh MD, Park WB, Park SW, Choe PG, Bang JH, Song KH, et al. (March 2018). Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea. The Korean Journal of Internal Medicine. 33 (2) (2018) 233–246. doi:10.3904/kjim.2018.031. PMC 5840604. PMID 29506344.
[35] Ñamendys-Silva SA. Respiratory support for patients with COVID-19 infection. The Lancet. Respiratory Medicine. doi:10.1016/S2213-2600(20) (2020) 30110-7. PMID 32145829.
[36] Doucleef M, Scientists Go Deep On Genes Of SARS-Like Virus. Associated Press. Archived from the original on 2012-09-27. Retrieved 2012-09-27.
[37] Falco M. New SARS-like virus poses medical mystery. CNN Health. Archived from the original on 2013-11-01. Retrieved 2013-03-16.
[38] Kelland K. New virus not spreading easily between people: WHO. Reuters . Archived from the original on 2012-11-24. Retrieved 2013-03-16.
[39] Sang-Hun C. MERS Virus's Path: One Man, Many South Korean Hospitals. The New York Times. Archived from the original on 2017-07-15. Retrieved 2017-03-01.
[40] Cohen J. Wuhan seafood market may not be source of novel virus spreading globally. Science Mag American Association for the Advancement of Science. (AAAS). Archived from the original on 2020-01-27. Retrieved 2020-01-29.
[41] Eschner K. We're still not sure where the COVID-19 really came from. Popular Science . Archived from the original on 2020-01-30. Retrieved 2020-01-30.
[42] Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China. International Journal of Infectious Diseases. 91 (2020) 264–66. doi:10.1016/j.ijid. 2020.01.009. PMID 31953166.
[43] Eschner K. We're still not sure where the COVID-19 really came from. Popular Science. Archived from the original on 2020-01-30. Retrieved 2020, 1, 30.
[44] Murphy FA, Gibbs EP, Horzinek MC, Studdart MJ. Veterinary Virology. Boston: Academic Press. (1999) 495–508. ISBN 978-0-12-511340-3.
[45] Bande F, Arshad SS, Bejo MH, Moeini H, Omar AR, Progress and challenges toward the development of vaccines against avian infectious bronchitis. Journal of Immunology Research. 2015: 424860. doi:10.1155/2015/ 424860. PMC 4411447. PMID 25954763.
[46] Murray J (2014-04-16). "What's New With Ferret FIP-like Disease?" (xls). Archived from the original on 2014-04-24. Retrieved 2014-04-24.
[47] Weiss SR, Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus". Microbiology and Molecular Biology Reviews. 69 (4) (2005) 635–64. doi:10.1128/ MMBR.69.4.635-664.2005. PMC 1306801. PMID 16339739.
[48] Zhou P, Fan H, Lan T, Yang XL, Shi WF, Zhang W, et al. Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin. Nature. 556 (7700) (2018) 255–58. Bibcode:2018Natur.556 .255Z . doi:10.1038/s41586-018-0010-9. PMID 29618817.
[49] Tirotta E, Carbajal KS, Schaumburg CS, Whitman L, Lane TE. Cell replacement therapies to promote remyelination in a viral model of demyelination. Journal of Neuroimmunology. 224 (1–2)(2010)101–07. doi:10.1016/j.jneuroim.2010.05.013. PMC 2919340. PMID 20627412.
[50] Cruz JL, Sola I, Becares M, Alberca B, Plana J, Enjuanes L, Zuñiga S., Coronavirus gene 7 counteracts host defenses and modulates virus virulence. PLoS Pathogens.7 (6) (2011) e1002090. doi:10.1371/journal.ppat.1002090. PMC 3111541. PMID 21695242.
[51] Cruz JL, Becares M, Sola I, Oliveros JC, Enjuanes L, Zúñiga S. Alphacoronavirus protein 7 modulates host innate immune response. Journal of Virology. 87 (17) (2013) 9754–67. doi:10.1128/JVI.01032-13 . PMC 3754097. PMID 23824792.
[52] Wei X, She G, Wu T, Xue C, Cao Y. PEDV enters cells through clathrin-, caveolae-, and lipid raft-mediated endocytosis and traffics via the endo-/lysosome pathway. Veterinary Research. 51 (1) (2020) 10. doi:10.1186/s13567-020-0739-7. PMC 7011528. PMID 32041637.
[53] Thiel V (editor), Coronaviruses: Molecular and Cellular Biology (1st ed.). Caister Academic Press(2007) . ISBN 978-1-904455-16-5.
[54] Fan Y, Zhao K, Shi ZL, Zhou P. Bat Coronaviruses in China. Viruses. 11 (3)(2019)210. doi:10.3390/v11030210. PMC 6466186. PMID 30832341.
[55] De Groot RJ, Baker SC, Baric R, Enjuanes L, Gorbalenya AE, Holmes KV, Perlman S, Poon L, Rottier PJ, Talbot PJ, Woo PC, Ziebuhr J. Family Coronaviridae. In King AM, Lefkowitz E, Adams MJ, Carstens EB, International Committee on Taxonomy of Viruses, International Union of Microbiological Societies. Virology Division (eds.). Ninth Report of the International Committee on Taxonomy of Viruses. Oxford: Elsevier. (2011) 806–28. ISBN 978-0-12-384684-6.
[56] Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR. Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens. Journal of Virology. 90 (16) (2016) 7415–28. doi:10.1128/JVI.00080-16. PMC 4984655
[57] McIntosh K. Arber W, Haas R, Henle W, Hofschneider PH, Jerne NK, Koldovský P, Koprowski H, Maaløe O, Rott R (eds.). Coronaviruses: A Comparative Review. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitäts for schung. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitäts for schung. Berlin, Heidelberg: Springer: 87(1974) doi:10.1007/978-3-642-65775-7_3. ISBN 978-3-642-65775-7.
[58] Kahn JS, McIntosh K. History and recent advances in coronavirus discovery. The Pediatric Infectious Disease Journal. 24 (11Suppl) (2005) S223–27, discussion S226. doi:10.1097/01.inf.0 000188166.17324.60 . PMID 16378050.
[59] Geller C, Varbanov M, Duval RE. Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies.Viruses.4 (11) (2012) 3044–68. doi:10.3390/v 4113044. PMC 3509683. PMID 23202515.
[60] Almeida JD, Berry DM, Cunningham CH, Hamre D, Hofstad MS, Mallucci L, McIntosh K, Tyrrell DA. Virology: Coronaviruses. Nature. 220(5168)(1968)650. doi:10.1038/220650b0. PMC 7086490. [T]here is also a characteristic "fringe" of projections 200 A long, which are rounded or petal shaped..This appearance, recalling
[61] The solar corona, is shared by mouse hepatitis virus and several viruses recently recovered from man, namely strain B814, 229E and several others.
[62] Sturman LS, Holmes KV . Lauffer MA, Maramorosch K (eds.). The molecular biology of coronaviruses. Advances in Virus Research. 1983, 28: 35–112. doi:10.1016/s0065-3527(08)60721-6. PMID 6362367. [T]hese viruses displayed a characteristic fringe of large, distinctive, petal-shaped peplomers or spikes which resembled a crown, like the corona spinarum in religious art; hence the name coronaviruses.
[63] Goldsmith CS, Tatti KM, Ksiazek TG, Rollin PE, Comer JA, Lee WW, Ultrastructural characterization of SARS coronavirus". Emerging Infectious Diseases., 10 (2) (2004) 320–26. doi:10.3201/ eid1002.030913. PMC 3322934 . PMID 15030705.
[64] Fehr AR, Perlman S . Maier HJ, Bickerton E, Britton P (eds.). Coronaviruses: an overview of their replication and pathogenesis. Methods in Molecular Biology. Springer. 2015, 1282: 1–23. doi:10.1007 /978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. PMC 4369385. PMID 25720466. See section: Virion Structure.
[65] Neuman BW, Adair BD, Yoshioka C, Quispe JD, Orca G, Kuhn P. Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy. Journal of Virology, 80 (16) (2006) 7918–28. doi:10.1128/JVI.00645- 06. PMC 1563832. PMID 16873249. Particle diameters ranged from 50 to 150 nm, excluding the spikes, with mean particle diameters of 82 to 94 nm;
[66] Chang CK, Hou MH, Chang CF, Hsiao CD, Huang TH. The SARS coronavirus nucleocapsid protein--forms and functions. Antiviral Research. 103 (2014) 39–50. doi:10.1016/j.antiviral. 2013.12.009 . PMID 24418573.
[67] Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, et al. A structural analysis of M protein in coronavirus assembly and morphology. Journal of Structural Biology. 174 (1) (2011)11– 22. doi:10.1016/j.jsb.2010.11.021. PMC 4486061. PMID 21130884.
[68] Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LL, et al. Unique and conserved features of genome and proteome of SARScoronavirus, an early split-off from the coronavirus group 2 lineage. Journal of Molecular Biology. 331 (5) (2003) 991– 1004. doi:10.1016/S0022-2836(03)00865-9. PMID 12927536.
[69] Simmons G, Zmora P, Gierer S, Heurich A, Pöhlmann S. Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research. Antiviral Research. 100 (3)(2013) 605– 14. doi:10.1016/j.antiviral.2013.09.028. PMC 3889862. PMID 241210 34.
[70] Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR. Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens. Journal of Virology. 90 (16) (2016) 7415– 28. doi:10.1128/JVI.00080-16. PMC 4984655
[71] Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. In Maier HJ, Bickerton E, Britton P (eds.). Coronaviruses. Methods in Molecular Biology. 1282. Springer. (20105) 1–23. doi:10. 1007/978-1-4939-2438-7_1. ISBN 978-1-4939- 2438-7. PMC 4369385. PMID 25720466.
[72] Masters PS. The molecular biology of coronaviruses". Advances in Virus Research. Academic Press. 66(2006) 193– 292. doi:10.1016/S0065-3527(06)66005-3. ISBN 978- 0120398690. PMI D 16877062 .
[73] Cui J, Li F, Shi ZL, Origin and evolution of pathogenic coronaviruses. Nature Reviews. Microbiology. 17 (3) (2019) 181– 92. doi:10.1038/s41579-018-0118-9. PMID 30531947. Different SARS-CoV strains isolated from several hosts vary in their binding affinities for human ACE2 and consequently in their infectivity of human cells 76, 78 .
[74] Li F, Li W, Farzan M, Harrison SC. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 309 (5742) (2005) 1864–68. Bibcode:2005Sci.309.1 864L. doi:10.1126 /science.1116480. PMID 16166518.
[75] Wertheim JO, Chu DK, Peiris JS, Kosakovsky Pond SL, Poon LL. A case for the ancient origin of coronaviruses. Journal of Virology. 87 (12) (2013) 7039–45. doi:10.1128/JVI.03273- 12. PMC 367 6139. PMID 23596293.
[76] Woo PC, Lau SK, Lam CS, Lau CC, Tsang AK, Lau JH, et al. Discovery of seven novel Mammalian and avian coronaviruses in the genus delta coronavirus supports bat coronaviruses as the gene source of alpha coronavirus and beta coronavirus and avian coronaviruses as the gene source of gamma coronavirus and delta coronavirus. Journal of Virology. 86 (7) (2012) 3995– 4008. doi:10.1128/JVI.0 6540-11. PMC 3302495. PMID 22278237.
[77] Bidokhti MR, Tråvén M, Krishna NK, Munir M, Belák S, Alenius S, Cortey M. Evolutionary dynamics of bovine coronaviruses: natural selection pattern of the spike gene implies adaptive evolution of the strains. The Journal of General Virology. 94 (Pt 9) (2013) 2036– 49. doi:10.1099/vir.0.054940-0. PMID 23804565.
[78] Vijgen L, Keyaerts E, Moës E, Thoelen I, Wollants E, Lemey P. Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. Journal of Virology. 79 (3)(2005) 1595–604. doi:10.1128/ jvi.79.3. 1595-1604.2005. PMC 544107 . PMID 15650185.
[79] Lau SK, Lee P, Tsang AK, Yip CC, Tse H, Lee RA. Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination. Journal of Virology. 85 (21) (2013) 11325–37. doi:10.1128/JVI.0 5512-11. PMC 3194943 . PMID 21849456.
[80] Lau SK, Li KS, Tsang AK, Lam CS, Ahmed S, Chen H. Genetic characterization of Beta coronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus. Journal of Virology. 87 (15) (2013) 8638–50. doi:10.1128/JVI.01055-13. PMC 3719811. PMID 23720729.

Keywords
mutation ,Covide.19 ,Corona Virus, infection.